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Novel thiazolidines of potential anti-proliferation properties against esophageal squamous cell carcinoma via ERK pathway

https://doi.org/10.1016/j.ejmech.2022.114909

Aziz, Marian N.; Nguyen, Linh; Chang, Yan; Gout, Delphine; Pan, Zui; Lovely, Carl J. (January 2023, European Journal of Medicinal Chemistry)

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One-Pot Synthesis of Novel 2-Imino-5-Arylidine-Thiazolidine Analogues and Evaluation of Their Anti-Proliferative Activity against MCF7 Breast Cancer Cell Line

https://doi.org/10.3390/molecules27030841

Aziz, Marian N.; Patel, Arzoo; Iskander, Amany; Chini, Avisankar; Gout, Delphine; Mandal, Subhrangsu S.; Lovely, Carl J. (February 2022, Molecules)

An efficient surface-mediated synthetic method to facilitate access to a novel class of thiazolidines is described. The rationale behind the design of the targeted thiazolidines was to prepare stable thiazolidine analogues and evaluate their anti-proliferative activity against a breast cancer cell line (MCF7). Most of the synthesized analogues exhibited increased potency ranging from 2–15-fold higher compared to the standard reference, cisplatin. The most active thiazolidines contain a halogenated or electron withdrawing group attached to the N-phenyl ring of exocyclic 2-imino group. However, combination of the two substituents did not enhance the activity. The anti-proliferative activity was measured in terms of IC50 values using an MTT assay.
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Dearomatizing spirocyclization of thioureas, ureas and guanidines

https://doi.org/10.1016/j.tetlet.2021.153054

Aziz, Marian N.; Singh, Ravi P.; Gout, Delphine; Lovely, Carl J. (May 2021, Tetrahedron Letters)
null (Ed.)
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Ene reactions of pre-aromatic heterocycles – Oxazoles

https://doi.org/10.1016/j.tetlet.2021.153134

Singh, Ravi P.; Fulton, Brandon B.; Phan, Huy T.; Gout, Delphine; Lovely, Carl J. (June 2021, Tetrahedron Letters)
null (Ed.)
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